The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function.
Periodo de realización: 1900/01/01 al 2005/01/01
Tipo: Artículo científico
Lugar(es) de estudio: Cuernavaca, Mor., México
Resumen: "The venom of the scorpion Tityus costatus contains peptides toxic to humans but scarce information on their structure and function is available. Here, we report the separation of 50 different components by high performance liquid chromatography and the identification of approximately 90 distinct components by mass spectrometry analysis, with molecular weights varying from 413 to 45482 atomic mass units. Four peptides were fully sequenced: (i) a butantoxin-like peptide that blocks Shaker K+ channel"