Mapping knowledge translation and innovation processes in cancer drug development : the case of liposomal doxorubicin
Cita: David Fajardo Ortíz, Luis Durán, Laura Moreno, Héctor Ochoa, Víctor M. Castaño. 2014. Mapping knowledge translation and innovation processes in cancer drug development: the case of liposomal doxorubicin. Journal of Translational Medicine. 12. DOI:10.1186/s12967-014-0227-9.
En: Journal of Translational Medicine. Vol. 12, no. (2014)ISSN: 1479-5876
Fecha de realización: 2014/05/31
Tipo: Artículo con arbitraje
Resumen: "We explored how the knowledge translation and innovation processes are structured when theyresult in innovations, as in the case of liposomal doxorubicin research. In order to map the processes, a literature network analysis was made through Cytoscape and semantic analysis was performed by GOPubmed which is based in the controlled vocabularies MeSH (Medical Subject Headings) and GO (Gene Ontology). We found clusters related to different stages of the technological development (invention, innovation and imitation) and the knowledge translation process (preclinical, translational and clinical research), and we were able to map the historic emergence of Doxil as a paradigmatic nanodrug. This research could be a powerful methodological tool for decision-making and innovation management in drug delivery research. "