Inhibition of Iodine Transport with Perchlorate Alters the Redox Balance in Trophoblast

Periodo de realización: 1900/01/01 al 2021/01/01

Tipo: Artículo científico

Lugar(es) de estudio: Veracruz, 91020 Xalapa-Enríquez, Ver., México
Resumen: "Iodine deficiency is a risk factor of preeclampsia, perchlorate (KCLO4) blockade iodine transport. Previous studies done in trophoblast cells show that that KCLO4 induce loss of differentiation and aberrant increase of migration process. Oxidative stress may contribute to endothelial dysfunction, in order to determine the effect of KCLO4 and iodine exposure on the antioxidant and oxidative stress status we use trophoblast cells. Results shown an increase in lipoperoxidation, CAT and SOD enzymatic activity in KCLO4 trophoblast cells with a P <0.05, although introphoblast cells treated with iodine after elimination of NIS blockade was observed a decrease in the activity of SOD and CAT, being significant with 100 ?M since 24 hours of treatment(P <0.001). This study show that KCLO4 cause alterations in equilibrium REDOX, however, other studies are required to corroborate the mechanisms of action of iodine in the antioxidant status."

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